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背景:抽动秽语综合征(tourettesyndrome,TS)患儿的学习和社会适应能力有一定障碍,对TS患者适应行为能力的评估,有助于弥补TS所致的功能缺损。目的:比较TS患儿与正常儿童的适应行为能力,寻找进行干预的可能性。设计:以患者和正常学生为研究对象,横断面的病例-对照,观察对比研究。单位:一所大学医院儿科。对象:1999-10/2001-10就诊于首都医科大学附属北京安定医院儿科门诊以及住院患儿33例(患儿组),纳入标准为符合ICD-10TS诊断标准的知情同意的患者。男17例,女16例。对照组为同期随机抽自北京市一普通小学2～5年级学生,共33名,男16名,女17名,无TS、注意缺陷多动障碍、品行问题和情绪问题,经老师和家长同意后加入研究。方法:采用儿童适应行为量表对33例TS患儿和33名正常儿童进行了评定。主要观察指标:儿童适应行为评定量表评分。结果:TS患儿除感觉运动(23.7±0.6)和时空定向项目(11.7±3.0)与正常儿童(23.6±0.7,12.8±3.2)接近外,其他分量表、因子和适应能力商数均低于正常儿童,差异有统计学显著意义(t=3.21～11.91,P<0.05～P<0.01),且与该病的严重程度呈负相关(r=-0.377～0.661,P<0.05～0.01)。结论:TS患儿的适应能力评估对TS的严重程度的判断有重要作用,对治疗措施的拟订有指导意义。
BACKGROUND: Children with Tourette Syndrome (TS) have some barriers to learning and social adaptability. Assessment of adaptive capacity in patients with TS may help to make up for TS-induced functional impairment. OBJECTIVE: To compare the adaptive capacity of children with normal children with TS to find out the possibility of intervention. Design: Patients and normal students as the research object, cross-sectional case-control, observe the comparative study. Unit: a university hospital pediatrics. PARTICIPANTS: From October 1998 to October 2001, 33 pediatric outpatients and children hospitalized in Beijing Anding Hospital Affiliated to Capital University of Medical Sciences were enrolled in this study. Patients with informed consent under the ICD-10TS diagnostic criteria were enrolled. 17 males and 16 females. The control group was randomly selected from grade 2 to grade 5 primary school students in Beijing in the same period, with 33 males and 16 females and 17 females without TS, attention deficit hyperactivity disorder, conduct problems and emotional problems. The teachers and parents agreed After joining the study. Methods: 33 children with TS and 33 normal children were assessed using the Child Adaptive Behavior Inventory. MAIN OUTCOME MEASURES: Child Adaptive Behavior Rating Scale. Results: In addition to sensory movement (23.7 ± 0.6) and spatial-temporal orientation (11.7 ± 3.0) in TS subjects compared with normal children (23.6 ± 0.7, 12.8 ± 3.2), all other subscales, factors and fitness quotients were lower than The difference was statistically significant (t = 3.21 ~ 11.91, P <0.05 ~ P <0.01), and was negatively correlated with the severity of the disease (r = -0.377 ~ 0.661, P <0.05 ~ 0.01). Conclusion: The assessment of adaptive abilities in children with TS plays an important role in judging the severity of TS, which is instructive for the formulation of treatment measures.