论文部分内容阅读
目的研究慢性乙型肝炎患者血清可溶性白细胞介素-2受体(sIL-2R)和胰岛素样生长因子-1(IGF-1)与外周血淋巴细胞凋亡的关系,并探讨其临床意义。方法分别采用放射免疫分析法和流式细胞计数仪检测慢性乙型肝炎患者血清sIL-2R、IGF-1和外周血淋巴细胞凋亡率。结果慢性乙型肝炎患者血清sIL-2R、IGF-1水平和外周血淋巴细胞凋亡率明显高于正常对照组。随着患者肝脏病变程度的加重,外周血淋巴细胞凋亡率和血清sIL-2R水平逐步升高,而IGF-1水平则逐步降低。慢性乙型肝炎患者外周血淋巴细胞凋亡率与血清sIL-2R水平呈正相关,与IGF-1水平呈负相关。结论慢性乙型肝炎患者外周血淋巴细胞凋亡的异常与血清sIL-2R、IGF-1水平的异常有关,三者的变化与患者肝脏病变程度相关。
Objective To study the relationship between serum soluble interleukin-2 receptor (sIL-2R) and insulin-like growth factor-1 (IGF-1) and peripheral blood lymphocyte apoptosis in patients with chronic hepatitis B and to investigate its clinical significance. Methods Serum levels of sIL-2R, IGF-1 and peripheral blood lymphocytes in patients with chronic hepatitis B were measured by radioimmunoassay and flow cytometry respectively. Results Serum sIL-2R, IGF-1 levels and peripheral blood lymphocyte apoptosis rate in patients with chronic hepatitis B were significantly higher than those in the normal control group. With the severity of liver disease in patients, peripheral blood lymphocytes apoptosis and serum sIL-2R levels gradually increased, while the level of IGF-1 was gradually reduced. Chronic hepatitis B patients with peripheral blood lymphocyte apoptosis rate and serum sIL-2R levels were positively correlated, and IGF-1 levels were negatively correlated. Conclusion The abnormality of peripheral blood lymphocyte apoptosis in patients with chronic hepatitis B is related to abnormal levels of serum sIL-2R and IGF-1. The changes of the three are related to the degree of liver lesion in patients.