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皂苷是存在于中药中的一类较复杂的糖苷类化合物。生物转化是利用各种酶体系对天然活性化合物进行合成与结构修饰。利用生物转化技术能对皂苷完成一些有机合成难以进行的反应,得到更具新药开发价值的目标化合物。综述近几年微生物和游离酶转化技术对皂苷结构修饰的研究进展,并探讨其生物转化研究的发展方向。
Saponins are a group of more complex glycosides existing in traditional Chinese medicine. Biotransformation is the use of various enzyme systems for the synthesis of natural active compounds and structural modifications. Biotransformation technology can be used to complete the saponin some organic synthesis difficult reaction, the more the development of new drugs target value of the compound. In this paper, the research progress on the structural modification of saponins by microorganisms and free enzyme transformation in recent years is reviewed, and the development of biotransformation research is also discussed.