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宫颈癌的标准治疗为手术和放疗。近年来随着化疗新药的不断开发和化疗方案的改进,宫颈癌的化疗取得了突破性进展,尤其是新辅助化疗(NACT)的临床应用,对术前或放疗前缩小肿瘤体积,控制亚临床转移,改善无瘤生存期起重要作用。综述NACT的适应症、化疗方案及途径,及其对不同期别、不同病理类型宫颈癌的疗效等,并从临床和分子水平上分别阐述影响宫颈癌预后的因素。
The standard treatment for cervical cancer is surgery and radiotherapy. In recent years, with the continuous development of new chemotherapeutic drugs and the improvement of chemotherapy regimens, breakthroughs have been made in the chemotherapy of cervical cancer, especially the clinical application of neoadjuvant chemotherapy (NACT), which can reduce the tumor volume before operation or before radiotherapy, Transfer, improve disease-free survival plays an important role. To summarize the indications, chemotherapy regimens and pathways of NACT, and its curative effect on different stages and different pathological types of cervical cancer, and to elucidate the factors influencing the prognosis of cervical cancer from clinical and molecular level respectively.