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目的 :研究地尔硫、硝苯地平联合用于环孢素治疗肾移植并发高血压的长期疗效。方法 :将 40例经环孢素治疗的肾移植并发高血压患者随机分为治疗组和对照组各 2 0例 ,治疗组给予地尔硫 ,每次 3 0mg ,po ,bid ;硝苯地平每次 10mg ,po ,tid。对照组只给予硝苯地平 ,用法同治疗组。根据血压控制情况 ,调整治疗组地尔硫和对照组硝苯地平剂量。对患者进行 >2a的临床观察 ,观察患者血药浓度及动脉血压、肾功能。结果 :地尔硫干扰环孢素代谢 ,导致环孢素剂量降低 40 .0 % ,但未见其增强环孢素肾毒性。两组的平均血压水平相似 ,维持在正常范围内。两组肾功能差异无显著性 (P >0 .0 5 )。结论 :地尔硫、硝苯地平联用于肾移植并发高血压症 ,安全有效 ,并能节约肾移植患者的费用
Objective: To study the long-term efficacy of diltiazem combined with nifedipine in the treatment of renal transplant complicated with hypertension by cyclosporine. Methods: Forty patients with renal transplantation complicated with hypertension treated with cyclosporine were randomly divided into treatment group and control group with 20 cases each. Diltiazem was given to the treatment group with 30 mg, po, bid each time. Nifedipine Each 10mg, po, tid. The control group was given only nifedipine, with the same treatment group. According to the situation of blood pressure control, the dose of nifedipine in the treatment group and the control group were adjusted. Patients> 2a clinical observation, observation of patients with plasma concentration and arterial blood pressure, renal function. RESULTS: Diltiazem interfered with cyclosporine metabolism, resulting in a 40.0% reduction in cyclosporine dosage, but no enhancement of cyclosporine nephrotoxicity was seen. The mean blood pressure was similar in both groups and remained within the normal range. There was no significant difference in renal function between the two groups (P> 0.05). Conclusion: Diltiazem, nifedipine combined with renal transplantation for hypertension, safe and effective, and can save the cost of kidney transplant patients