子痫前期是妊娠期特发性母体全身动脉内皮细胞激活、进展性炎症反应致多器官功能障碍性疾病，发病机制尚不清楚。转化生长因子β1（ TGF－β1）是一类含多种生物活性的多肽生长因子，具有调节细胞增殖与分化、胚胎发育、血管生成、免疫抑制等功能。子痫前期与 TGF－β1的表达异常相关，而TGF－β1基因多态性影响其转录和翻译，可能与子痫前期的发生、发展密切相关。“,”The clinical symptoms of multiple organ dysfunction of preeclampsia are preceded by an exag-gerated inflammatory response and generalized maternal endothelial cell activation ,but the mechanisms of this syndrome remain unclear.Transforming growth factor beta 1(TGF-β1) is a kind of polypeptide growth factor containing many kinds of biological activity , which regulates cell proliferation and differentiation , embryo development,angiogenesis,immunosuppression and other functions.The TGF-β1 abnormal expression is asso-ciated with preeclampsis,the gene polymorphisms of which affects its transcription and translation , thus is possibly closely associated with the onset and development of preeclampsia .