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长程免疫抑制剂治疗HBsAg阳性慢性活动性肝炎(下称慢活肝)是有害的。它不但延迟其生化的缓解并使病人的存活率降低,而且还常发生各种并发症,如糖尿病、结核病及(氵弥)慢性皮肤真菌感染等。近年来发现,这类病人经长程或短程免疫抑制治疗后停药时常出现血清转氨酶的上升以及DNA多聚酶的下降。为了评价这种疗法,本文作者对HBsAg阳性慢活肝病人进行了10周短程强的松治疗及停药后的临床观察,同时检测其血清转氨酶水平及乙型肝炎病毒标志。治疗组及对照组各18例病人,两组在年龄、性别、种族等各方面都是可比的。开始时,强
Long-term immunosuppressive agents are harmful to the treatment of HBsAg-positive chronic active hepatitis (hereinafter referred to as slow-living liver). It not only delays its biochemical remission and reduces the patient’s survival rate, but also often complies with various complications such as diabetes, tuberculosis and chronic skin fungal infections. In recent years, found that such patients after long-term or short-course immunosuppressive therapy often appear after the withdrawal of serum aminotransferase and DNA polymerase decreased. In order to evaluate this therapy, the authors of the HBsAg-positive chronic active liver disease in patients with short-course prednisone for 10 weeks and after stopping the clinical observation, at the same time detect the serum aminotransferase levels and hepatitis B virus markers. The treatment group and the control group of 18 patients, the two groups in age, gender, race and other aspects are comparable. The beginning, strong