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目的:评价阿德福韦酯对肝癌患者术后伴乙肝病毒感染抗病毒治疗的临床疗效。方法:选取2014年5月—2016年4月期间收治的肝癌术后伴乙型肝炎病毒感染患者188例,将其分为观察组和对照组,每组94例;对照组患者给予施行肝癌切除术治疗,观察组患者在对照组基础上术后给予阿德福韦酯治疗,比较两组患者分别治疗后的不同时段时肝功能各指标和HBV-DNA测得值,以及并发症的发生率。结果:术后第7天,观察组患者肝功能各指标测得值明显低于对照组(P<0.05),HBV-DNA测得值明显低于对照组(P<0.05),并发症的发生率低于对照组(P<0.05)。结论:采用阿德福韦酯治疗肝癌患者术后伴乙肝病毒感染,抗病毒感染的临床疗效显著,患者术后肝功能各指标复常较快,并发症的发生率较低。
Objective: To evaluate the clinical effect of adefovir dipivoxil on antiviral treatment of patients with hepatocellular carcinoma after hepatitis B virus infection. Methods: A total of 188 patients with hepatocellular carcinoma who were infected with hepatitis B virus during the period from May 2014 to April 2016 were selected and divided into observation group and control group, with 94 cases in each group. Patients in the control group were given hepatectomy Patients in the observation group were given adefovir dipivoxil postoperatively on the basis of the control group. The indexes of liver function and HBV-DNA in different periods after treatment were compared between the two groups, and the incidence of complications . Results: On the 7th day after operation, the measured values of liver function in the observation group were significantly lower than those in the control group (P <0.05), and the values of HBV-DNA in the observation group were significantly lower than those in the control group (P <0.05) The rate was lower than that of the control group (P <0.05). Conclusion: Adefovir dipivoxil treatment of liver cancer patients with hepatitis B virus infection, the clinical efficacy of antiviral infection was significant, the patients with postoperative liver function faster recovery, the incidence of complications is low.