目的 :研制一种用于治疗内痔出血的中药栓剂。方法 :将单味大黄粉碎成黄豆粒大 ,70 %乙醇回流提取流浸膏 ,真空干燥、粉碎成 12 0目细粉 ,加入其它基质制成栓剂后 ,进行药效学、毒理实验及临床疗效观察。结果 :药效学中对断尾小鼠出血有明显的止血作用 ;对小鼠凝血作用与对照组洗必泰栓组作用相似 ;对体外肠道常见感染菌高度敏感。结论 :速效内痔止血栓对内痔出血有肯定的治疗作用。 Objective: To develop a traditional Chinese medicine suppository for hemorrhage of internal hemorrhoids. Methods: Single rhubarb was crushed into large soybeans, 70% ethanol reflux extraction extract, vacuum-dried, crushed into 12-mesh fine powder, and added into other suppositories to perform pharmacodynamics, toxicological experiments and clinical Efficacy observation. RESULTS : In pharmacodynamics, hemostasis was evident in mice with severed tails; the clotting effect in mice was similar to that in the control group chlorhexidine suppository; and it was highly sensitive to common intestine infections in vitro. Conclusion : The quick-acting internal hemorrhoidal thrombosis has a positive therapeutic effect on internal hemorrhage.