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目的 :寻找晚期食管癌的有效治疗方法。 方法 :自 1995年 3月至 1998年 4月以DLF方案 (顺铂、醛氢叶酸、5 -氟脲嘧啶 )加与不加羟基喜树碱 (HCPT)治疗晚期食管癌。结果 :治疗组有效率 6 8.7% ,而对照组为 43.3% ,差异显著 (P <0 .0 5 )。主要毒副作用为纳差、恶心或呕吐 ,其发生率为 85 .3% ,但多为Ⅰ～Ⅱ级 ;白细胞下降在治疗组和对照组分别为 82 .4%和 6 3.4% ,差异不具有统计学意义 (P >0 .0 5 ) ,Ⅲ～Ⅳ级白细胞下降少见 ;血小板下降两组分别为 35 .3%和 10 % ,差异显著 (P <0 .0 5 ) ,但亦多为Ⅰ～Ⅱ级 ;口腔粘膜炎和腹痛、腹泻等副作用也比较轻。结论 :我们认为DLFH方案治疗晚期食管癌安全有效 ,是一种可行的方案。
Objective: To find an effective treatment for advanced esophageal cancer. Methods: From March 1995 to April 1998, advanced esophageal cancer was treated with DLF regimen (cisplatin, alduronic acid and 5 - fluorouracil) with or without hydroxycamptothecin (HCPT). Results: The effective rate was 67.7% in the treatment group and 43.3% in the control group, with significant difference (P <0.05). The main side effects were anorexia, nausea or vomiting, the incidence was 85.3%, but mostly Ⅰ ~ Ⅱ grade; leukopenia in the treatment group and the control group were 82.4% and 6 3.4%, the difference does not have Statistical significance (P> 0.05), Ⅲ ~ Ⅳ grade leukopenia is rare; thrombocytopenia were 35.3% and 10%, respectively, the difference was significant (P <0.05), but also mostly I ~ Ⅱ level; oral mucositis and abdominal pain, diarrhea and other side effects are relatively mild. Conclusion: We think DLFH regimen is a safe and effective treatment of advanced esophageal cancer, which is a feasible solution.