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目的 探讨血管瘤内皮细胞功能及其病因学意义。方法 采用放射免疫和硝酸还原酶法测定儿童血管瘤 30例瘤体内皮素 (ET)、一氧化氮 (NO)及外周血ET、NO水平 ,以 2 0例斜疝患儿外周血作为对照。结果 血管瘤患儿瘤体ET(6 6 .3± 12 .5 )pg/ml显著高于外周血 (5 5 .3± 13.1)pg/ml(P <0 .0 1) ,外周血ET与对照组 (5 4 .4± 15 .1) pg/ml相比差异无显著性意义 (P >0 .0 5 )。增生期血管瘤体ET(75 .6± 12 .5 ) pg/ml高于退化期 (6 5±10 .2 ) pg/ml及退化完成期 (6 2 .5± 7.3) pg/ml(P <0 .0 5 )。血管瘤体NO(32 .5± 9.3) pg/ml与外周血 (37.5± 5 .2 ) pg/ml和正常对照组 (39.5±8.8) pg/ml无差异 (P >0 .0 5 ) ,但增生期瘤体NO(2 7.9± 2 .1) pg/ml降低 (P <0 .0 1)。结论 增生期血管瘤内皮细胞具有活跃的合成分泌ET的功能 ,而合成分泌NO功能改变不明显 ,局部ET与NO水平的失调 ,可能与血管内皮的过度增生有关
Objective To investigate the function of endothelial cells of hemangiomas and their etiological significance. Methods Totally 30 children with hemangiomas were treated with radioimmunoassay and nitrate reductase method for determination of endothelin (ET), nitric oxide (NO) and ET, NO in peripheral blood. Twenty children with hernia were used as control. Results The levels of ET (66.3 ± 12.5) pg / ml in hemangiomas were significantly higher than those in peripheral blood (53.3 ± 13.1) pg / ml (P <0.01) There was no significant difference between the control group (54.4 ± 15.1) pg / ml (P> 0.05). The proliferative hemangioma ET (75.6 ± 12.5) pg / ml was higher than the degenerative stage (65 ± 10.2) pg / ml and the degenerative stage (65.2 ± 7.3) pg / ml <0 .0 5). No difference was found between NO (32.5 ± 9.3) pg / ml and peripheral blood (37.5 ± 5.2) pg / ml and normal control group (39.5 ± 8.8) pg / ml However, NO (2 7.9 ± 2. 1) pg / ml in the proliferative phase decreased (P <0.01). Conclusions Endothelial cells of proliferative hemangiomas have active functions of synthesizing and secreting ET, but the changes of NO secretion are not obvious. The imbalance of ET and NO levels may be related to the hyperplasia of vascular endothelium