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长期慢性高脂血症损伤动脉壁促使动脉粥样硬化病变形成,已有较多报导,但急性高脂血症对血管壁的影响研究较少。我们以往实验结果得出,一次静脉注射高脂血清后3小时家兔主动脉壁组织耗氧量明显增加,主动脉内膜对伊文思兰——白蛋白结合物的通透性显著升高。但高脂血清对血管壁的这种早期损伤作用的机理尚未阐明。考虑到血小板功能改变在上述反应中的可能作用,我们测定了实验性高脂血症家兔血液中血小板和血小板微聚物数,并观察了一次静脉注射高脂血清后兔血小板和血小板微聚物的变化;为分析高脂血清影响血小板功能的可能途径,我们还观察了预先用利血平处理动物对这种变化的影响。
Long-term chronic hyperlipidemia damage arterial wall to promote the formation of atherosclerotic lesions, there have been many reports, but the impact of acute hyperlipidemia on the vascular wall is less research. Our previous experimental results show that the oxygen consumption of aortic wall tissue in rabbits increased significantly after an intravenous injection of hyperlipidemia for 3 hours, and the permeability of the aortic intima to Evans blue albumin conjugate was significantly increased. However, the mechanism of this early damage effect of high-fat serum on the blood vessel wall has not yet been elucidated. Considering the possible role of platelet function changes in the above reaction, we measured the number of platelet and platelet micro-polymers in the blood of experimental hyperlipidemia rabbits, and observed the rabbit platelet and platelet micro-aggregation after one intravenous hyperlipidemia. Changes in substances; To analyze the possible pathways of high-fat serum affecting platelet function, we also observed the effect of pretreatment with reserpine on this change.