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目的观察米氮平对睡眠剥夺小鼠学习记忆以及海马组织脑源性神经营养因子前体(proBDNF)和成熟体(mBDNF)表达的影响。方法 32只雄性小鼠随机均分为空白对照组(KB组)、模型对照组(MX组)、米氮平2.5mg/kg组(M1组)和米氮平10mg/kg组(M2组)。MX组、M1组和M2组小鼠灌胃16d后采用小平台水环境法建立24-h睡眠剥夺模型,采用Morris水迷宫实验观察小鼠学习记忆功能的变化。随后取海马组织测定其proBDNF和mBDNF含量。结果与KB组比较,MX组小鼠上台时间延长(P<0.01),穿越平台次数减少(P<0.05),海马proBDNF表达增加(P<0.01),mBDNF表达减少(P<0.01);与MX组比较,M2组小鼠上台时间缩短(P<0.05),穿越台次数增加(P<0.05),海马proBDNF表达减少(P<0.05),mBDNF表达增加(P<0.05)。结论米氮平能有效地减轻小鼠睡眠剥夺引起的学习记忆障碍,其作用可能与海马proBDNF表达降低和mBDNF表达增加有关。
Objective To observe the effects of mirtazapine on the learning and memory and the expressions of brain-derived pro-BDNF and mBDNF in hippocampus of mice after sleep deprivation. Methods 32 male mice were randomly divided into blank control group (KB group), model control group (MX group), mirtazapine 2.5 mg / kg group (M1 group) and mirtazapine 10 mg / kg group . Mice in MX group, M1 group and M2 group were given 24-h sleep deprivation model by water platform method after 16 days of gavage. Morris water maze test was used to observe the changes of learning and memory in mice. Subsequent hippocampal tissue was measured proBDNF and mBDNF content. Results Compared with the KB group, the MX group mice had longer progessive time (P <0.01) and decreased the number of passing through the platform (P <0.05), the expression of proBDNF in the hippocampus increased (P <0.01) and the expression of mBDNF decreased Compared with the control group, the number of pro-BDNF in hippocampus decreased (P <0.05) and the expression of mBDNF increased in M2 group (P <0.05). Conclusion Mirtazapine can effectively alleviate the learning and memory impairment induced by sleep deprivation in mice, which may be related to the decreased expression of proBDNF and the increase of mBDNF in hippocampus.