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我国生殖毒理学研究在 60年代以评价化学物致畸效应为主 ;70年代有关刊物详尽描述了致畸和繁殖试验的方法 ;80年代制定的法规将喂养繁殖试验、喂养致畸试验和传统致畸试验列为必做试验 ,并在致突变试验项目中列出睾丸生殖细胞染色体畸变分析和精子畸形试验 ;90年代的研究内容已由单纯致畸研究扩大至男 (雄 )性和女 (雌 )性生殖和发育毒理 ,在研究手段上由整体动物实验扩大至全胚胎培养、组织培养、细胞培养 ,并运用了分子生物学理论和技术。现从生殖毒性测试的发展、观测生殖毒性指标的进展、化学物生殖毒性研究进展等几个角度对我国生殖毒理领域的研究作一概述 ,并提出今后的研究动向将会以生殖细胞遗传毒性研究、拓宽研究对象以及开展环境内分泌干扰物的研究为主
Reproductive and Toxicology in China in the 1960s to evaluate the main teratogenic effects of chemicals; publications in the 1970s a detailed description of the method of teratogenic and reproductive tests; regulations formulated in the 80’s feeding and breeding trials, feeding teratogenicity test and traditional induced Abnormal test as a must-do test, and in the mutagenicity test items listed in testicular germ cell chromosome aberration analysis and sperm abnormality test; the 90’s research has been expanded from simple teratogenic studies to male (male) and female ) Sexual reproduction and developmental toxicology, in the means of research by the whole animal experiments expanded to whole embryo culture, tissue culture, cell culture, and the use of molecular biology theory and technology. Now from the reproductive toxicity test development, observation of reproductive toxicity indicators of progress, chemical reproductive toxicity research progress on several aspects of the study of reproductive toxicology in China made an overview, and put forward the future research trends will germ cell genotoxicity Research, broaden the research object and carry out the research of environmental endocrine disruptors