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目的研究林下山参冻干粉的急性毒性和遗传毒性。方法采用最大耐受剂量法进行小鼠急性毒性试验,通过Ames试验、小鼠骨髓嗜多染红细胞微核试验和小鼠精子畸形试验检测林下山参冻干粉的遗传毒性。结果雌、雄小鼠对林下山参的最大耐受量(MTD)均>15.00 g/(kg·BW),属于无毒级物质;各剂量组的TA97、TA98、TA100、TA102菌株的回变菌落数与溶剂对照组比较,回变菌落数均未超过自发回变菌落数的1倍,亦无剂量-反应关系,结果为阴性;小鼠骨髓嗜多染红细胞微核试验和小鼠精子畸形试验中各剂量组微核率、精子畸形率与阴性对照组之间差异无统计学意义(P>0.05),而环磷酰胺阳性对照组与阴性对照组之间差异有统计学意义(P<0.01),显示试验结果均为阴性。结论在该试验条件下,林下山参冻干粉属于无毒级物质,亦不具有遗传毒性。
Objective To study the acute toxicity and genotoxicity of Linxia ginseng freeze-dried powder. Methods The maximum tolerated dose method was used to test the acute toxicity of mice. Ames test, mouse bone marrow polychromatic erythrocyte micronucleus test and mouse sperm abnormality test were used to detect the genotoxicity of Linxia ginseng freeze-dried powder. Results The MTD of female and male mice were all> 15.00 g / (kg · BW), which belonged to non-toxic substances. The regression of TA97, TA98, TA100 and TA102 strains of each dose group Compared with the solvent control group, the number of colonies returned did not exceed 1 times of the number of spontaneous colonies, and there was no dose-response relationship. The result was negative. The micronucleus test of mouse bone marrow polychromatic erythrocytes and mouse sperm deformity There was no significant difference between micronucleus rate, sperm deformity rate and negative control group in each dose group (P> 0.05), but the difference between cyclophosphamide positive control group and negative control group was statistically significant (P < 0.01), showing that the test results were negative. Conclusion Under the experimental conditions, Linxia ginseng freeze-dried powder is non-toxic substances, nor genotoxic.