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目的观察比较醒脑静注射液联合盐酸纳洛酮注射液和单用盐酸纳洛酮注射液治疗中、重度急性酒精中毒的临床疗效。方法将116例中、重度急性酒精中毒患者随机分为两组,醒脑静注射液联合盐酸纳洛酮注射液治疗组(治疗组)56例,盐酸纳洛酮注射液治疗组(对照组)60例。结果无论是共济失调期患者还是昏迷期患者,开始显效时间和病征减轻、病征消失时间等方面治疗组与对照组差异显著(P<0.01)。结论对于中、重度急性酒精中毒患者,盐酸纳洛酮和醒脑静合用疗效优于单用纳洛酮,有协同作用,见效快,值得推广应用。
Objective To observe the clinical effect of Xingnaojing injection combined with naloxone hydrochloride injection and naloxone hydrochloride injection alone in the treatment of moderate and severe acute alcohol poisoning. Methods One hundred and sixty-six patients with moderate and severe acute alcoholism were randomly divided into two groups: 56 cases in Xingnaojing injection combined with naloxone hydrochloride injection group (treatment group), naloxone hydrochloride injection group (control group) 60 cases. Results There was a significant difference between the treatment group and the control group (P <0.01) in patients with ataxia or coma, effective time and symptom relief, and disappearance of symptoms. Conclusion For patients with moderate and severe acute alcoholism, naloxone hydrochloride combined with xingnaojing is better than naloxone alone, which has synergistic effect and quick response, so it is worth popularizing and applying.