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近年来,临床观察到不少非内分泌腺组织发生的良、恶性肿瘤伴有各种内分泌异常表现。大多数病例临床表现类似于特异腺体分泌过高激素所致的症状。例如卵巢癌合并高血钙、低血磷;纤维瘤合并低血糖休克等。正常情况下,激素只产生于各自的内分泌腺细胞。但某些非内分泌腺组织肿瘤,特别是癌变时,可以产生其它内分泌腺所分泌的激素。这种激素或类激素物质称为异位激素(ectopic hormone)。由异位激素引起的内分泌紊乱的症状和生物化学变化,称为异位内分泌综合征或副激素综合征(para-hormone syndrome)。
In recent years, the clinical observation of many non-endocrine glands occur in benign and malignant tumors accompanied by a variety of endocrine abnormalities. The clinical manifestations of most cases are similar to the symptoms caused by hyperseborrheic hormone in specific glands. For example, ovarian cancer with hypercalcemia, hypophosphatemia; fibroids with hypoglycemia shock. Normally, hormones are produced only in their own endocrine cells. However, some non-endocrine gland tumors, especially cancerous, can produce hormones secreted by other endocrine glands. This hormone or hormone-like substance is called ectopic hormone. Symptoms and biochemical changes of endocrine disorders caused by an ectopic hormone are called ectopic endocrine syndrome or para-hormone syndrome.