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胃窦部幽门弯曲菌(CP)的慢性感染引起十二指肠溃疡(DU)的机制仍不清楚。作者在清除 CP 前后作了血清胃泌素浓度和胃酸度测定的对照研究。病人和方法 9例男性和1例女性患者,在近1年内内镜均确诊为 DU。近1月内内镜检查未见有活动性溃疡,但胃窦部活检标本病理显示为 CP 相关性胃炎,快速尿素酶试验阳性。患者均用过 H_2受体拮抗剂治疗。研究前及治疗后4周(三钾二枸椽酸络合铋120mg,甲硝咪唑400mg,羟氨苄青霉素200mg,均每日3次,疗程1月)作~(14)C-尿素呼气试验、24小时胃酸度和血清胃泌素测定。把接有自动记数器的玻璃电
The mechanism of chronic infection of Campylobacter pylori (CP) causing duodenal ulcer (DU) remains unclear. The authors performed a controlled study of serum gastrin concentrations and gastric acidity before and after CP removal. Patients and Methods Nine men and one woman were diagnosed with DU by endoscopy within a year. Endoscopic examination within 1 month showed no active ulcers, but the pathology of gastric sinus biopsy showed CP-related gastritis, rapid urease test was positive. Patients were treated with H 2 receptor antagonists. Pre-study and 4 weeks after treatment (triple potassium citrate complex bismuth 120mg, metronidazole 400mg, amoxicillin 200mg, were 3 times a day, the course of treatment in January) for ~ (14) C-urea breath test , 24-hour gastric acidity and serum gastrin assay. Put the automatic counter is connected to the glass of electricity