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本文对52例恶性肿瘤患者放射治疗前后与50名健康人的血清纤维联结蛋白(Fn)的检测结果进行比较。结果表明放疗前肿瘤患者的血清Fn值(118.8±39.7μg/ml)明显低于健康人(186.9±39.4)(P<0.001);放疗后(154.9±53.1)比放疗前有显著升高(P<0.001);本组中病例较多的鼻咽癌、其他头颈部癌、食管癌、脑瘤和乳腺癌患者的平均Fn值均升至健康人水平(P>0.2—0.5)。检测血清Fn可作为判断疗效和预后的一种简便方法。
This article compared the results of the detection of serum fibronectin (Fn) in 50 healthy individuals before and after radiation therapy. The results showed that the serum Fn value (118.8±39.7μg/ml) was significantly lower in patients before radiotherapy (118.8±39.7μg/ml) than in healthy individuals (186.9±39.4) (P<0.001); after radiotherapy (154.9±53.1), it was significantly higher than before radiotherapy (P). <0.001); The average Fn values of patients with nasopharyngeal carcinoma, other head and neck cancers, esophageal cancer, brain tumors, and breast cancer in this group all increased to healthy people (P>0.2-0.5). Detection of serum Fn can be used as a simple method to determine the efficacy and prognosis.