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为了探讨胆结石的形成机理,筛选有效的溶石、防石的中西药物,我们于1980年起,进行制选豚鼠胆色素结石的动物模型及药物防治的实验研究,并分析了胆汁的成分,对肝胆组织作切片染色、显微镜和电镜检查等工作。结果表明:喂致石饮食的豚鼠,60天天后胆囊结石发生数点91％,动物结石经扫描电镜、病理切片、物理化学分类证实,与人体胆色素类结石基本相似,产生结石豚鼠的胆汁与我国胆色素结石病人的胆汁特点相似,如游离胆红素升高,β—葡萄糖醛酸酶活力升高等。结石的产生与细菌感染和胆道
In order to investigate the mechanism of gallstone formation and screen for effective Chinese and Western drugs for dissolution of stone and stone, we have conducted animal studies on the selection of animal models of guinea pig gallstones and drug control since 1980 and analyzed the composition of bile. Hepatobiliary tissue for staining, microscopy and electron microscopy examinations. The results showed that gallstones in the guinea pig fed with dietary citrate diet had 91% of gallstones after 60 days. Animal stones were confirmed by scanning electron microscopy, pathological sections, and physical and chemical classifications. These stones were similar to human gallstone pigments and produced biliary guinea pig bile. Bile pigmentary stones in patients with bile characteristics in China are similar, such as elevated free bilirubin, β-glucuronidase activity increased. Stone production with bacterial infections and biliary tract