β-肾上腺素受体拮抗剂心得安的抗高血压作用已被证明与抑制中枢交感神经冲动密切有关。本文探讨了这种作用的脑内神经通路,特别是与抑制性神经元γ-氨基丁酸(GABA)神经元的关系。在麻醉家兔,分别用氨基脲75mg/kg 静脉注射预处理以抑制 GABA 合成;普鲁卡因1mg脑内注射以阻止 GABA 释放;苦味毒1mg/kg The antihypertensive effect of beta-adrenergic receptor antagonist propranolol has been shown to be closely related to the inhibition of central sympathetic nerve impulses. This paper explores the role of this pathway in neural circuits in the brain, in particular with the GABA neurons of inhibitory neurons. In anesthetized rabbits, pretreatment with semicarbazide 75 mg / kg, respectively, was performed to inhibit GABA synthesis; 1 mg of procaine was injected intracerebrally to prevent GABA release; bitterness 1 mg / kg