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硫酸类肝素在人类的某些重大疾病如癌症、艾滋病、老年痴呆症中扮演着一些重要的角色,因而是现今糖类化合物中研究的热门焦点之一.近年的研究表明,硫酸类肝素中所含的微量结构,即N-非取代葡萄糖胺残基有着重要的生物学与病理生理学作用.它与病毒的侵入、脑组织损伤、蛋白聚糖的体内循环等作用密切相关.对硫酸类肝素中N-非取代葡糖胺残基的结构、功能及其生物体内合成途径的研究将有助于揭示某些疾病的发病机制,为改善诊断方法和发展药物提供可能.本文综述近10多年来国内外在该领域的最新研究进展.
Heparin sulfate plays a number of important roles in certain major human diseases such as cancer, AIDS and Alzheimer’s disease, and is therefore one of the hot topics in the research of carbohydrate nowadays.Recent studies show that heparan sulfate Containing the trace structure, that is, N-substituted glucosamine residues have important biological and pathophysiological effects, which is closely related to the invasion of viruses, brain tissue damage, the role of proteoglycans in vivo circulation and so on.For sulfuric acid heparin Studies on the structure, function and biosynthetic pathway of N-substituted glucosamine residues will help to reveal the pathogenesis of certain diseases and provide the possibility of improving the diagnostic methods and drugs.In this article, The latest research progress in this area.