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抗肾小球基底膜(GBM)抗体介导的急进性肾炎属新月体肾炎Ⅰ型,国内较为少见。临床特点为起病急,进展快,短期内即可出现进行性肾功能不全,预后很差。我们对4例抗GBM抗体性肾炎进行了血浆置换、甲基强的松龙冲击等综合强化治疗,其中2例患者行经皮重复肾活检观察治疗的近期疗效,旨在为临床治疗本病提供一定的经验。
Anti-glomerular basement membrane (GBM) antibody-mediated acute nephritis is a crescentic nephritis type I, the more common in China. Clinical features of acute onset, rapid progress, progressive renal failure can occur in a short time, the prognosis is poor. We conducted 4 cases of anti-GBM antibody nephritis with plasma exchange, methylprednisolone shock and other comprehensive intensive treatment, of which 2 patients underwent percutaneous repeated renal biopsy to observe the short-term efficacy of treatment, designed to provide clinical treatment of the disease experience of.