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用5只狗进行了16次食物唾液条件反射实驗,每次实驗給药5—10天,其中11次实驗单給HCT,5次是与NaCl或KCl合用。結果表明,动物每天口服HCT10,20或50毫克/公斤时,阳性条件反射量明显降低,潜伏期延长,有时出現位相变化,有1只狗的分化抑制解除。非条件反射改变較少。单独应用HCT及与KCl或NaCl合用时条件反射的改变相似。 HCT引起的血压下降与原血压水平有关。原血压水平在正常范圍的狗,服药后血压未下降,1只腎型高血压狗在每天口服HCT50毫克/公斤时血压下降較明显,当补充NaCl或KCl时,血压不再下降。本实驗結果表明,HCT对条件反射和对心血管系統的影响在作用机制上不尽相同。
Six food saliva conditioned reflex experiments were performed with five dogs, each of which was administered for 5-10 days, of which 11 were given HCT alone and 5 were combined with NaCl or KCl. The results showed that when the animals were orally given HCT10, 20, or 50 mg / kg orally, the positive reflexes were significantly reduced, the latency was prolonged, and the phase changes sometimes occurred. One dog’s inhibition of differentiation was relieved. Non-conditional reflections change less. HCT alone and similar changes in conditioned reflexes when combined with KCl or NaCl. HCT-induced drop in blood pressure and the level of the original blood pressure. The original blood pressure level in the normal range of dogs, after taking the blood pressure did not decline, a kidney-type hypertensive dogs daily oral HCT50 mg / kg when the blood pressure decreased significantly when the supplement of NaCl or KCl, the blood pressure no longer decreased. The experimental results show that HCT on the conditioned reflex and the cardiovascular system in the mechanism of action is not the same.