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目的探讨清热解毒凉血方联合蒙脱石散剂对感染性腹泻患儿CRP水平的影响。方法随机选择本院门诊及病房的感染性腹泻患儿150例。男86例,女64例;年龄6个月～5岁。病毒性肠炎66例,男36例,女30例;细菌性肠炎84例,男50例,女34例。将患儿按治疗方案不同随机分为治疗1组、治疗2组和对照组。治疗1组采用清热解毒凉血方保留灌肠,每日1次,共用5 d;治疗2组在治疗1组的基础上口服蒙脱石散剂,疗程同治疗1组;对照组仅口服蒙脱石散剂。观察治疗前、治疗3 d及5 d CRP水平的变化,并追踪随访至15 d。结果治疗前,细菌性肠炎组CRP水平显著高于病毒性肠炎组(P<0.01)。治疗前,治疗1组、治疗2组及对照组3组间CRP水平差异无统计学意义(P>0.05);治疗3 d、5 d,治疗1组、治疗2组及对照组CPR水平与各自治疗前比较CPR水平均明显降低,差异均有统计学意义(Pa<0.01);治疗2组CRP水平显著低于治疗1组及对照组(P<0.01,0.05)。结论检测CRP有助于细菌性肠炎与病毒性肠炎的鉴别;清热解毒凉血方联合蒙脱石散剂对降低感染性腹泻患儿CRP效果良好。
Objective To investigate the effect of Qingre Jiedu Duoxue Decoction combined with montmorillonite powder on CRP level in children with infectious diarrhea. Methods A total of 150 children with infectious diarrhea in our clinic and ward were randomly selected. 86 males and 64 females; aged 6 months to 5 years old. 66 cases of viral enteritis, 36 males and 30 females; 84 cases of bacterial enteritis, 50 males and 34 females. The children were randomly divided into treatment group 1 treatment group, treatment 2 and control group. Treatment group 1 with Qingrejiedu cooling blood side retention enema, once daily for 5 days; treatment group 2 in the treatment of a group based on oral montmorillonite powder, treatment with the same treatment group 1; control group only oral montmorillonite Powder. The changes of CRP levels at 3 days and 5 days after treatment were observed and followed up for 15 days. Results Before treatment, CRP level in bacterial enteritis group was significantly higher than that in viral enteritis group (P <0.01). There was no significant difference in CRP levels between treatment group 1, treatment group 2 and control group 3 before treatment (P> 0.05). The levels of CRP in treatment group 1, treatment group 2 and control group at 3 d, 5 d, The levels of CPR in the two groups before treatment were significantly lower than those in the other two groups (P <0.01, 0.05). The levels of CRP in the treatment two groups were significantly lower than those in the treatment one group and the control group (P <0.01, 0.05). Conclusions The detection of CRP is helpful to the identification of bacterial enteritis and viral enteritis. The combination of detoxification, heat-clearing and blood-removing prescription and montmorillonite powder has a good effect on reducing CRP in children with infectious diarrhea.