雌激素在乳腺癌病因学中起着关键的作用。研究表明,雌激素可使激素依赖性乳腺癌持续生长。如果切断雌激素的来源,如切除卵巢、使用抗雌激素治疗等,肿瘤将明显退化。去势或绝经后妇女服用生理剂量的雌激素可刺激肿瘤生长。研究资料均表明,雌激素是乳腺癌的促有丝分裂剂,但对于雌激素是否直接作用于肿瘤细胞以促其生长,目前尚未获得确切的证据。本文综合作者近期的研究结果,提出如下四项假说。Ⅰ.雌激素直接刺激乳腺癌细胞亦在 Estrogen plays a key role in the etiology of breast cancer. Studies have shown that estrogen can make hormone-dependent breast cancer continued to grow. If you cut off the source of estrogen, such as ovariectomy, the use of anti-estrogen therapy, the tumor will be significantly degraded. Ovarieal or postmenopausal women taking physiological doses of estrogen can stimulate tumor growth. Research data show that estrogen is a mitogenic agent of breast cancer, but no direct evidence of estrogen on tumor cells to promote its growth. This article synthesizes the author’s recent research results and proposes the following four hypotheses. Estrogen directly stimulates breast cancer cells