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目的 研究正常晚期妊娠和常见妊娠并发症孕妇血清β-绒毛膜促性腺激素 (β-human chorionicgonadotropin,β-HCG)和雌三醇 ( E3)含量变化及相关性 ,探讨其临床应用价值。方法 分别对 550例正常晚期妊娠和 164例妊娠并发症孕妇测定血清β-HCG和 E3 含量并进行相关性分析。结果 1妊高征患者血清β-HCG含量明显高于正常妊娠者 ,其增加值与妊高征严重程度呈正相关 ( P<0 .0 5) ,而 E3 含量随妊高征病情加重而降低。 2胎儿宫内生长迟缓( intrauterine growth retardation,IUGR)患者血清β-HCG含量明显高于正常妊娠者 ( P<0 .0 5) ,而 E3 含量明显低于正常妊娠者 ( P<0 .0 1)。 3过期妊娠 NST试验无反应型患者血清β-HCG明显高于正常妊娠者 ( P<0 .0 1) ,而 E3 含量明显低于正常妊娠者 ( P<0 .0 1)。结论 妊娠晚期血清β-HCG增高发生妊娠并发症的机会增多 ,临床可作为一种筛选试验 ,如同时行 E3 测定更易及时准确反映胎盘功能受损状况
Objective To study the changes and correlations of serum β-human chorionicgonadotropin (β-HCG) and estriol (E3) levels in pregnant women with normal late pregnancy and common pregnancy complications and to explore their clinical value. Methods Serum levels of β-HCG and E3 in 550 normal pregnant women and 164 pregnant women with pregnancy complications were measured and analyzed respectively. Results The serum level of β-HCG in PIH patients was significantly higher than that in normal pregnancy patients. The added value was positively correlated with the severity of PIH (P <0.05), but E3 decreased with the increase of PIH. Serum β-HCG levels in patients with intrauterine growth retardation (IUGR) were significantly higher than those in normal pregnancy (P <0.05), while E3 levels were significantly lower in patients with normal pregnancy (P <0.01) ). Serum levels of β-HCG in non-responsive patients in the NST trial were significantly higher than those in the normal pregnancy (P <0.01), while those in the EST were significantly lower than those in the normal pregnancy (P <0.01). Conclusion Pregnancy has a higher chance of pregnancy complicating pregnancy with elevated β-HCG, which can be used as a screening test. It is more easy and timely to accurately reflect the placenta functional impairment in time