采用T-迷宫延迟交替作业试验,研究了人参(Panax ginseng)水提取物对东莨菪碱诱导的大鼠空间作业记忆破坏的作用。东莨菪碱(0.025～0.1mg/kg,ip)能损伤迷宫行为,并有剂量依赖性;毒扁豆碱(0.4mg/kg)明显逆转东莨菪碱(0.1mg/kg)诱导的行为缺损。试验前给大鼠经口投与人参提取物(0.5～4.0g干燥根/kg)60分钟,能改善东莨菪碱(0.1mg/kg)诱导的迷宫行为破坏,并有剂量依赖性。在饮 The effects of Panax ginseng water extract on scopolamine-induced spatial memory impairment in rats were investigated using a T-maze delay alternating test. Scopolamine (0.025-0.1 mg/kg, ip) can damage the labyrinth behavior in a dose-dependent manner; physostigmine (0.4 mg/kg) significantly reversed behavioral deficits induced by scopolamine (0.1 mg/kg). Before the experiment, rats were orally administered ginseng extract (0.5-4.0 g dry root/kg) for 60 minutes to improve scopolamine (0.1 mg/kg)-induced labyrinth behavioral destruction in a dose-dependent manner. In drinking