Imipramine protects retinal ganglion cells from oxidative stress through the tyrosine kinase recepto

来源 :中国神经再生研究(英文版) | 被引量 : 0次 | 上传用户:jiangyoung
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Retinal ganglion cell (RGC) degeneration is irreversible in glaucoma and tyrosine kinase receptor B (TrkB)-associated signaling pathways have been implicated in the process. In this study, we attempted to examine whether imipramine, a tricyclic antidepressant, may protect hydrogen peroxide (H2O2)-induced RGC degeneration through the activation of the TrkB pathway in RGC-5 cell lines. RGC-5 cell lines were pre-treated with imipramine 30 minutes before exposure to H2O2. West blot assay showed that in H2O2-damaged RGC-5 cells, imipramine activated TrkB pathways through extracellular signal-regulated protein kinase/TrkB phosphorylation. TUNEL staining assay also demonstrated that imipramine ameliorated H2O2-induced apoptosis in RGC-5 cells. Finally, TrkB-IgG intervention was able to reverse the protective effect of imipramine on H2O2-induced RGC-5 apoptosis. Imipramine therefore protects RGCs from oxidative stress-induced apoptosis through the TrkB signaling pathway.
其他文献
第3届亚太区国际帕金森病研讨会于2001年12月2~3日在香港会展中心举行,来自世界各地及港台地区约600余名医生参加了会议,中国内地有近20人与会,其中王新德、陈清棠、张振馨、
期刊
期刊
目的探讨改良Cloward前路减压融合术联合术中电生理监护治疗颈椎病的疗效.方法借助显微镜和高速磨钻对60例颈椎病患者进行颈前入路椎管内显微减压术,植骨后并使用钛板固定;术
目的调查北京市丰台区方庄社区70岁以上老年男性原发性骨质疏松症(OP)患病率及其相关的临床危险因素。方法根据入选和排除标准于2014年1—10月在北京市丰台区方庄社区采用广
急性重症呼吸道综合征(SARS)是一种新出现的病毒性传染病.2003年3月在新加坡暴发流行.本文描述了该暴发指征病例及其密切接触者病例的临床特征、实验室结果和胸部X光片特点.
SARS以惊人的速度在全球范围内播散,几个星期内波及许多医院和公共卫生机构.至2003年4月14日,全球已有超过20个国家有疫情发生,共有临床诊断病例3 169例.在许多地区,疾病由感
Flavonoids are a major component in the traditional Chinese medicine RadixIlicis Pubescentis. Previous studies have shown that the administration of RadixIlicis
Acupuncture can be used to treat various nervous system diseases. Here, 168 vascular dementia patients were orally administered donepezil hydrochloride alone (5
患者女,5岁,因右前胸、上腹壁红肿、疼痛伴发热1周,于1999年2月12日入院.既往史:1995年10月在外院诊断“①交通性脑积水;②脑膜脑膨出”在我院行右侧脑室-腹腔分流术.检查:体