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作者采用单剂苯巴比妥预防脑型疟所致惊厥。该药具有疗效确切,用途广泛,价廉等特点,并且肌注后有最佳的生物利用度。 48例患脑型疟,且有6年以上病史的患者参加了双盲对照试验。将患者随机等分成两组。两组中有11例患者在进入试验前均出现过惊厥,且临床和实验室检查指标均相似.此外,治疗组有7例,对照组3例处于深度昏迷状态。在进入试验后,病人随机接受苯巴比妥钠(深部肌肉注射)或生理盐水。体重在60kg以上的病人每次注射200mg苯巴比妥,体重低于60kg者注射3.5mg/kg。试验中记录每个病人的用药剂量、时间以及惊厥发作的
The authors use a single dose of phenobarbital to prevent seizures caused by cerebral malaria. The drug has the exact effect, uses a wide range of features such as low cost, and intramuscular injection of the best bioavailability. 48 patients with cerebral malaria who had a history of over 6 years participated in a double-blind controlled trial. Patients were randomly divided into two groups. Eleven patients in both groups had convulsions before entering the trial, and clinical and laboratory tests were similar. In addition, seven patients in the treatment group and three patients in the control group were in a deep coma. After entering the trial, patients were randomized to receive sodium phenobarbital (deep intramuscular injection) or saline. Patients weighing more than 60kg each injected with 200mg phenobarbital, weighing less than 60kg were injected 3.5mg / kg. The trial recorded the dose of each patient, time, and seizures