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目的:综合分析并科学探究马钱子总生物碱对实验性关节炎的临床治疗效果影响,以期能够分析出马钱子总生物碱的相关组成部分,为治疗实验性关节炎患者提供重要的数据参考。方法:从马钱子中提取相关生物碱,在此基础上分离出以下3个部分:其一,非生物碱;其二,士的宁(番木鳖碱);其三,总生物碱。通过对上述3个部分的分析观察对角叉菜胶(Diagonal fork)所导致的棉球致肉芽(Cotton caused granulation)组织增生以及大鼠足肿胀的情况出现。结果:马钱子的总生物碱部分能够有效控制住大鼠足肿胀的情况出现,马钱子的生物碱部分能够显著控制住棉球致肉芽组织的增生情况(控制率达到38.74%);非生物碱与士的宁(番木鳖碱)部分没有明显的控制作用,2组数据比较有较大差异,具有统计学意义(p<0.05)。结论:马钱子的总生物碱部分有着比较理想的抗炎作用,但是非生物碱与士的宁(番木鳖碱)部分是无效的组成部分。
OBJECTIVE: To comprehensively analyze and scientifically explore the clinical effects of total alkaloids of Strychnos nux vomica on experimental arthritis in order to analyze the related components of total alkaloids of Strychnos nux-vomica and provide important data for the treatment of patients with experimental arthritis . Methods: The related alkaloids were extracted from Strychnos nux vomica, and the following three parts were separated on the basis of this: First, non-alkaloids; Second, strychnine (strychnine); Third, total alkaloids. Analysis of the above three sections was carried out to observe the occurrence of cotton caused granulation tissue hyperplasia and rat foot swelling caused by Diagonal fork. Results: The total alkaloid fraction of Strychnos nux-vomica could effectively control the foot swelling in rats. The alkaloid fraction of Strychnos nux-vomica could significantly control the proliferation of granulation tissue caused by cotton balls (control rate was 38.74%). Alkaloids and strychnine (strychnine) part of no significant control, the two groups of data have more significant differences, with statistical significance (p <0.05). CONCLUSIONS: The total alkaloid fraction of Strychnos nux vomica has an ideal anti-inflammatory effect, but the non-alkaloids and strychnine (strychnine) fraction are ineffective components.