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为广探讨速尿试验改善梅尼埃病前庭功能的可能机理，应用钙离子选择性微电极观察速尿对正常及实验性膜迷路积水豚鼠的前庭壶腹嵴内电位（AEP）及其内淋巴Ca2＋活度的影响。结果表明，实验性膜迷路积水动物AEP显著下降（P＜0．001），Ca2+活度明显升高（P＜0．01）。经静注10mg／kg速尿约6min的潜伏期后，AEP评始下降，40min达最低，为3．04±0．53mV，但与注射前比较地显著性差异。Ca2+活度于60min上升至最高，为（710±1．32）×10－4M，80min开始回落。结果支持小剂量速尿对实验膜迷路积水前庭有直接作用。并就Ca2＋在速尿试验作用机理中的意义进行讨论。
To explore the possible mechanism of furosemide test to improve the function of Meniere’s vestibular system, the potential effect of furosemide on vestibular amputation potential (AEP) in normal and experimental membranous labyrinthine guinea pigs was observed by calcium ion selective microelectrode Effect of Lymph Ca2 + Activity. The results showed that AEP in experimental membranous hydrocephalus decreased significantly (P <0.001) and Ca2 + activity increased significantly (P <0.01). After intravenous injection of 10mg / kg furosemide for about 6min incubation period, AEP began to decline, reaching a minimum of 40min, 3.04 ± 0.53mV, but significant difference compared with before injection. The activity of Ca2 + increased to the highest level at 60min, which was (710 ± 1.32) × 10-4M, which began to decline after 80min. The results support the low-dose furosemide on the experimental membrane lost water vestibule has a direct effect. The significance of Ca2 + in the furosemide test mechanism was also discussed.