目前慢性肾功能衰竭 (CRF)在许多动物如猪、豚鼠、兔、猫、羊、狗、大鼠、小鼠等已诱导成功 ,所用的方法有外科手术、冷冻、电凝、结扎、药物、免疫等 ,每种方法都有自己的长处与不足。选择适当的建模方法有助于更好地进行CRF的实验和临床研究。故本文对有关建立CRF动物模型的原理、方法及特点作一综述 ,期望能对CRF的治疗和研究提供一些参考 Currently, chronic renal failure (CRF) has been induced successfully in many animals such as pigs, guinea pigs, rabbits, cats, sheep, dogs, rats, mice and the like. The methods used include surgery, freezing, electrocoagulation, ligation, Immune, etc., each method has its own strengths and weaknesses. Choosing the right modeling method will help make CRF experiments and clinical studies better. Therefore, this article reviews the principles, methods and features of establishing animal models of CRF, and hopes to provide some references for the treatment and research of CRF