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本研究观察了六味地黄汤对中老龄大鼠下丘脑—垂体—性腺轴系统的器官的形态学及血清性腺激素水平的影响，以探讨“肾主生殖”的作用机理。结果表明：六味地黄汤能够升高ＬＨ、Ｔ的浓度，并能降低ＦＳＨ的浓度，而对Ｅ２浓度无影响。同时对大鼠的垂体、精囊有增重作用，并能增加垂体ＬＨ细胞的数量，并改变其形态结构；对ＦＳＨ细胞则有减少的作用；对睾丸无增重作用，但能够改善睾丸间质细胞及曲细精管的结构。分析认为六味地黄汤治疗生殖功能减退的机理为其作用于下丘脑—垂体—性腺轴系统各个层次的综合效应。本实验为临床治疗男性生殖功能障碍等疾病提供了理论依据。
This study was to observe the effects of Liuwei Dihuang Decoction on the morphology and serum gonadal hormone levels of hypothalamic-pituitary-gonadal axis organs in middle-aged rats to explore the mechanism of action of “kidney-based reproduction”. The results showed that: Liuwei Dihuang Decoction can increase the concentration of LH, T, and can reduce the concentration of FSH, but no effect on E2 concentration. At the same time, it can increase the weight of the pituitary and seminal vesicles of rats, and increase the number of pituitary LH cells, and change its morphological structure; It has a reduced effect on FSH cells; It has no weight-increasing effect on the testis, but can improve the testicular stroma The structure of cells and seminiferous tubules. The analysis suggests that the mechanism of Liuwei Dihuang Decoction in treating reproductive dysfunction is its comprehensive effect on the various layers of the hypothalamus-pituitary-gonadal axis system. This experiment provides a theoretical basis for clinical treatment of male reproductive dysfunction and other diseases.