论文部分内容阅读
目的研究耐多药肺结核患者血清中VEGF在γ-干扰素治疗前后的定量表达。方法将60例耐多药肺结核患者随机分为两组,试验组(30例)应用γ-干扰素+化疗药物,而对照组(30例)只应用化疗药物。用ELISA法检测两组化疗前后VEGF的含量。结果试验组患者在治疗后血清中VEGF的含量低于对照组治疗后,两者差异有统计学意义(P<0.05)。试验组患者血清中VEGF的含量在治疗前后差异有统计学意义(P<0.05)。结论经γ-干扰素治疗后,患者血清中VEGF的含量明显下降,证明γ-干扰素可抑制耐多药肺结核患者血清中VEGF的生成。γ-干扰素抑制肺结核患者细胞血管形成是其抗结核的机制之一。
Objective To study the quantitative expression of serum VEGF in patients with multidrug-resistant pulmonary tuberculosis before and after γ-interferon treatment. Methods Sixty MDR-TB patients were randomly divided into two groups. The experimental group (n = 30) received interferon-γ and chemotherapeutic drugs, while the control group (n = 30) received chemotherapy alone. The levels of VEGF in both groups before and after chemotherapy were detected by ELISA. Results The serum level of VEGF in the experimental group was lower than that in the control group after treatment, the difference was statistically significant (P <0.05). The content of VEGF in serum of experimental group had significant difference before and after treatment (P <0.05). Conclusions After IFN-γ treatment, the content of VEGF in serum decreased obviously, which proves that IFN-γ can inhibit the production of VEGF in the serum of MDR-TB patients. Interferon-γ inhibits the formation of blood vessels in patients with tuberculosis is one of its anti-TB mechanism.