作者评价了轮状病毒疫苗的首次剂量在6周时(42天)接种以取代在2月龄时接种的潜在影响。这种疫苗在美国建议在2月龄时进行接种,作者评价了提前接种首剂对轮状病毒病住院后的影响。作者应用公布的住院率资料、疫苗覆盖率资料以及一剂疫苗接种后的有效性资料,评估了在美国投递疫苗后血清转换的情况。 The authors evaluated the potential impact of the first dose of rotavirus vaccine at 6 weeks (42 days) to replace the vaccination at 2 months of age. The vaccine, which is recommended for vaccination at the age of 2 months in the United States, evaluated the impact of preemptive first doses on hospitalizations for rotavirus disease. The authors assessed published seroconversion after the vaccine was delivered in the United States using published hospitalization rate data, vaccine coverage data, and availability information after a single dose of vaccination.