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对活产儿有关人类染色体结构重排的突变率和频率方面的研究已有大量资料,人们几乎不怎么注意在自发流产儿中出现的染色体结构异常、虽然它的频率比活产儿约高10倍。本文把对自发流产儿的系统研究中所观察到的染色体结构异常和在活产儿中观察到的资料相比较,两者结合起来估计各类染色体结构重排的突变率、频率和意义。(一)平衡的结构重排:平衡的结构重
There is a wealth of information on the rate of mutation and the frequency of rearrangements of human chromosomes in live births and little attention has been paid to the chromosomal structural abnormalities that occur in spontaneous abortion although it is about 10 times more frequent than in live births. In this paper, the chromosomal structural abnormalities observed in the systematic study of spontaneous abortion were compared with those observed in live births, and the combination of them was used to estimate the mutation rate, frequency and significance of rearrangements of various chromosomal structures. (A) balanced structure rearrangement: balanced structure weight