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目的:探讨多种生化指标对早期脂肪肝的诊断价值,同时评价生化指标与患者肝损伤程度的关系。方法:将象山县红十字台胞医院所收治的120例脂肪肝患者纳入观察组,并根据患者病情分组为轻度、中度及重度,各30例,另选择同期健康体检的健康人群60例为对照组;抽取所有研究对象血液,并检测其各项生化指标,如丙氨酸氨基转移酶(ALT)、胆碱酯酶(CHE)等。结果:1观察组患者各项血清学指标均较对照组显著升高,P<0.05;2轻度、中度及重度患者TC、TG及血清酶水平比较,P>0.05;但三组间TBIL、CHE及DBIL水平比较,P<0.05,且随着患者病情加重,TBIL、CHE及DBIL水平也随之升高;3联合检测各项指标检出脂肪肝率明显高于单项检测各生化指标检出率,P<0.05;然各单项指标间检出率比较,P>0.05。结论:联合检测患者血清学各项指标有利于检测早期脂肪肝,且对患者病情判断具有指导意义。
Objective: To explore the diagnostic value of multiple biochemical indicators for early fatty liver, and to evaluate the relationship between biochemical indicators and the degree of liver injury in patients. Methods: One hundred and twenty cases of fatty liver patients admitted to Red Cross and Taiwanese Hospital of Xiangshan County were enrolled in the observation group. According to the patient’s condition, they were divided into mild, moderate and severe cases, 30 cases each, and another 60 healthy subjects As the control group. All the blood samples were drawn and their biochemical indexes such as alanine aminotransferase (ALT) and cholinesterase (CHE) were detected. Results: 1 The serological parameters in the observation group were significantly higher than those in the control group (P <0.05); 2 The levels of TC, TG and serum enzymes in the mild, moderate and severe patients were significantly higher than those in the control group (P> 0.05) , CHE and DBIL levels, P <0.05, and as the patient’s condition increased, TBIL, CHE and DBIL levels also increased; 3 combined detection of indicators of fatty liver was significantly higher than the detection of individual biochemical indicators The rate of, P <0.05; However, the detection rate between the individual indicators, P> 0.05. Conclusion: The combined detection of various serological indicators of patients is conducive to the detection of early fatty liver, and to guide the judgment of the patient’s condition.