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[目的]探讨放疗联合全身化疗对食管癌术后局部复发转移的疗效。[方法]52例纵隔和/或锁骨上复发及转移食管癌患者进行放射治疗,常规分割,DT48Gy～70Gy。22例放疗后予TP方案(紫杉醇+顺铂)化疗。[结果]全组总的中位生存期为12个月,1、2、3年生存率分别是48.1%、25.4%和14.0%。放化疗组1、2、3年生存率分别为77.3%、54.5%和31.8%,单纯放疗组1、2、3年生存率分别为50.0%、20.0%和6.7%(χ2=7.119,P=0.0076)。术后分期、放疗剂量、放疗后化疗及近期疗效与预后相关。[结论]放射治疗是食管癌术后局部复发和淋巴结转移的有效治疗方法,放疗结合化疗可能对患者有益。
[Objective] To investigate the curative effect of radiotherapy combined with systemic chemotherapy on local recurrence and metastasis of postoperative esophageal cancer. [Method] 52 patients with esophageal cancer who had mediastinal and / or supraclavicular recurrence and metastasis underwent radiotherapy and routinely divided into DT48Gy ~ 70Gy. Twenty-two patients underwent chemotherapy with TP regimen (paclitaxel + cisplatin) after radiotherapy. [Results] The overall median overall survival was 12 months. The 1, 2, 3-year survival rates were 48.1%, 25.4% and 14.0%, respectively. The 1-, 2- and 3-year survival rates of radiotherapy and chemotherapy group were 77.3%, 54.5% and 31.8%, respectively. The 1, 2 and 3-year survival rates of radiotherapy group were 50.0%, 20.0% and 6.7% respectively (χ2 = 7.119, 0.0076). Postoperative staging, radiotherapy dose, chemotherapy after radiotherapy and short-term efficacy were related to prognosis. [Conclusion] Radiation therapy is an effective treatment for local recurrence and lymph node metastasis of esophageal cancer patients. Radiotherapy combined with chemotherapy may be beneficial to patients.