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目的 :观察绿舒筋注射剂对大鼠的长期毒性 ,为临床安全用药提供依据。方法 :用Wistar大鼠 ,设高、中、低剂量组 ,剂量分别为 80 ,5 0 ,30g·kg-1生药和对照组 (0 .9%的氯化钠溶液 )。连续腹腔注射 12周 ,观察大鼠的饮食、体重。停药后处死2 / 3,1/ 3留作恢复期观察。取血测定血常规及其生化指标 ,并取出主要脏器作组织病理学检查。结果 :高、中剂量组的体重增长与对照组相比存在明显差异 ,在血常规、血生化、重要脏器体重比中 ,高剂量组的部分指标与对照组相比存在明显差异。结论 :当剂量为 80 g·kg-1时对大鼠肝脏有损伤作用 ,该药具有一定毒性。但停药后其损伤可得到恢复。
Objective : To observe the long-term toxicity of green Shujin injection on rats and provide basis for clinical safe drug use. METHODS: Wistar rats were divided into 80, 50, and 30 g·kg-1 crude drug groups and control groups (0.9% sodium chloride solution) at high, medium, and low doses. Continuous intraperitoneal injection for 12 weeks was performed to observe the rats’ diet and body weight. After the discontinuation of the drug, 2 / 3, 1 / 3 were observed for recovery. Blood was taken to determine the blood routine and its biochemical indicators, and the main organs were removed for histopathological examination. Results: There was a significant difference in weight gain between the high and middle dose groups compared with the control group. In the blood routine, blood biochemistry, and weight ratio of important organs, there were significant differences in some indicators of the high dose group compared with the control group. Conclusion : When the dose is 80 g·kg-1, the liver of rats will be damaged. The drug has certain toxicity. However, the damage can be restored after drug withdrawal.