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目的:探讨冠状动脉钙化患者血浆白介素(IL)-37水平的变化。方法:入选行冠状动脉CT检查发现冠状动脉钙化的患者48例,无冠状动脉钙化的30例患者为对照组。采用夹心酶联免疫法(ELISA)测定血浆IL-37和肿瘤坏死因子(TNF)-α,采用乳胶凝集比浊法检测超敏C反应蛋白(hs-CRP)水平。结果:冠状动脉钙化患者血浆IL-37(80.81±26.21)ng/L、TNF-α(12.53±3.44)ng/L和hs-CRP(2.66±3.89)mg/L水平高于对照组[IL-37(65.91±20.55)ng/L,P=0.010;TNF-α(10.51±3.73)ng/L,P=0.017;hs-CRP(1.12±0.81)mg/L,P=0.035]。相关性分析显示冠状动脉钙化患者血浆IL-37与TNF-α、hs-CRP水平、冠状动脉钙化Agatston积分正相关(分别r=0.410,P=0.004;r=0.481,P=0.001;r=0.354,P=0.013)。结论:新型抗炎因子IL-37可能与冠状动脉钙化的发生、发展密切相关。
Objective: To investigate the changes of plasma interleukin (IL) -37 in patients with coronary artery calcification. Methods: Forty-eight patients with coronary artery calcification and 30 patients without coronary artery calcification were enrolled in the coronary artery CT scan. Serum IL-37 and TNF-α were measured by sandwich enzyme-linked immunosorbent assay (ELISA), and the level of hs-CRP was detected by latex agglutination nephelometry. Results: The levels of plasma IL-37 (80.81 ± 26.21) ng / L, TNF-α (12.53 ± 3.44) ng / L and hs-CRP (2.66 ± 3.89) mg / L in patients with coronary artery calcification were significantly higher than those in the control group [IL- 37 (65.91 ± 20.55) ng / L, P = 0.010; TNF-α (10.51 ± 3.73) ng / L, P = 0.017, hs-CRP (1.12 ± 0.81) mg / L, P = 0.035]. Correlation analysis showed that there was a positive correlation between plasma IL-37 and TNF-α, hs-CRP and coronary calcification Agatston score in patients with coronary artery calcification (r = 0.410, P = 0.004; r = 0.481, P = 0.001; , P = 0.013). Conclusion: The new anti-inflammatory factor IL-37 may be closely related to the occurrence and development of coronary artery calcification.