论文部分内容阅读
经体内或体外方法接触致癌物的组织中,用放射自显影和亚细胞组份分离都已发现致癌物可与DNA结合。作者则用荧光显微镜直接证明了动物接受致癌物后,其细胞质和细胞核中有致癌物的存在。作者选用了下列经紫外线激发可产生荧光的致癌物:苯(α)芘(BP)、N-2-芴基乙酰胺(FAA)、黄曲霉毒素B_1(AFB)、5-氧代-5H-苯(c)异氧萘(4,3-b)吲哚(R 47)、苯(c)萘并(1,2-j)甲基-4-吖啶(BNMA)(原文为benzo(c)naphto(1,2-j)methyl-4-acridine,
Autoradiography and subcellular fractionation of autologous tissue in contact with carcinogens in vivo or in vitro have shown that carcinogens can bind to DNA. The authors directly demonstrated by fluorescence microscopy the presence of carcinogens in the cytoplasm and nucleus of animals after receiving carcinogens. The authors selected the following carcinogens that were excited by ultraviolet light to produce fluorescence: phenyl (α) hydrazine (BP), N-2-mercaptoacetamide (FAA), aflatoxin B_1 (AFB), 5-oxo-5H- Benzene (c) Isoxononaphthalene (4,3-b) fluorene (R 47), Benzene (c) Naphtho(1,2-j)methyl-4-acridine (BNMA) (Originally benzo(c) )naphto(1,2-j)methyl-4-acridine,