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目的 :观察尿毒症患者血清透明质酸 (HA)、Ⅳ型胶原 (CL -Ⅳ )、层粘蛋白 (LN)的变化及其相关性。方法 :测定了 2 1例尿毒症血液透析 (ESRD)组 ,2 1例原发性肾小球肾炎 (GN)组患者及 2 4例健康献血员 (NC)组的血清HA ,CL -Ⅳ ,LN水平 ,并作相关分析。结果 :ESRD组与GN组患者血清HA ,CL -Ⅳ及LN均高于NC组 (P <0 .0 1) ,ESRD组血清HA ,CL -Ⅳ ,LN水平高于GN组 ,有统计学意义 (P <0 .0 1) ;ESRD组患者血清HA ,CL -Ⅳ及LN变化 ,除HA与LN之间是呈正相关关系 (γ =0 .5 92 ,P <0 .0 5 )外 ,HA与CL -Ⅳ以及CL-Ⅳ与LN之间未显示相关性变化 (γ =0 .312 ,0 .177,P >0 .0 5 )。结论 :血清HA ,CL -Ⅳ ,LN联合检测可以反映并监测肾小球疾病的进展 ;ESRD患者细胞外基质主要成份血清水平之间变化 ,并非完全一致。
Objective: To observe the changes of serum hyaluronic acid (HA), type Ⅳ collagen (CL-Ⅳ) and laminin (LN) in patients with uremia and their correlation. Methods: The serum levels of HA, CL-Ⅳ, IL-6 and IL-6 in 21 patients with uremia hemodialysis (ESRD), 21 patients with primary glomerulonephritis (GN) and 24 healthy donors (NC) LN level, and make correlation analysis. Results: The serum levels of HA, CL-Ⅳ and LN in ESRD group and GN group were significantly higher than those in NC group (P <0.01). The serum levels of HA, CL-Ⅳ and LN in ESRD group were significantly higher than those in GN group (P0.01) .Serum levels of HA, CL-Ⅳ and LN in patients with ESRD were significantly higher than those in patients with ESRD (P0.05), except for a positive correlation between HA and LN (γ = 0.952, P0.05) There was no correlation between CL-IV and CL-IV and LN (γ = 0.321, 0.177, P> 0.05). Conclusion: The combined detection of serum HA, CL-Ⅳ and LN can reflect and monitor the progress of glomerular diseases. The serum levels of the major components of extracellular matrix in ESRD patients are not completely the same.