论文部分内容阅读
芋螺毒素由芋螺毒液管和毒囊内壁的毒腺所分泌,每种芋螺的毒液中至少含50~200种活性多肽。根据芋螺毒素高度保守的信号肽序列及二硫键骨架,芋螺毒素分为A、B1、B2、B3、C、D、E、F、G、H、I1、I2、I3、J、K、L、M、N、O1、O2、O3、P、S、T、V、Y等26个超家族。目前对A、O、M等超家族芋螺毒素研究较多,但新近发现的S、I、J、C、D、B1、B3、V、Y等超家族芋螺毒素的结构及功能报道较少,这些超家族具有复杂的翻译后修饰和独特的半胱氨酸骨架。本文对新近发现的S、I、J、C、D、B1、B3、V、Y等超家族芋螺毒素的序列、结构、作用靶点及功能进行简要综述。
Conotoxins are secreted by the venom of the taro venom tube and the inner wall of the venom sac and contain at least 50-200 active peptides in the venom of each species of taro. Conotoxins were classified into A, B1, B2, B3, C, D, E, F, G, H, I1, I2, I3, J, K according to the highly conserved signal peptide sequence of conotoxin and the disulfide backbone , 26 superfamilies of L, M, N, O1, O2, O3, P, S, T, V, At present, there are many studies on the conotoxins of A, O, M and other superfamilies. However, the structure and function of recently discovered conotoxins such as S, I, J, C, D, B1, B3, V, Fewer, these superfamilies have complex post-translational modifications and unique cysteine backbones. In this paper, the sequences, structures, targets and functions of newly discovered conus toxins such as S, I, J, C, D, B1, B3, V and Y were briefly reviewed.