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自1965年Rowe和Fahey发现一种新的骨髓瘤蛋白—IgD型后,世界上许多地区都相继报告了IgD骨髓瘤,这就促使许多人对IgD的结构、功能与生理、病理效应等问题进行了研究。 IgD在血清中平均浓度为30μg/ml,仅占血清免疫球蛋白总量的0.2～0.5％,尽管IgD在血清抗体中的作用还不清楚,但Rowe在人身上进行的研究及Vitetta在动物身上的研究都确定了IgD是一种细胞膜上主要的免疫球蛋白。
Since the discovery of a new myeloma protein-IgD type by Rowe and Fahey in 1965, IgD myeloma has been reported in many parts of the world, prompting many to question the structure, function, physiology and pathological effects of IgD Study. The average IgD concentration in serum is 30 μg / ml, accounting for only 0.2-0.5% of the total serum immunoglobulin. Although the role of IgD in serum antibodies is unclear, Rowe’s research on humans and Vitetta’s effects on animals Studies have determined that IgD is a major immunoglobulin on the cell membrane.