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蛋白质组学是在后基因组时代出现的一个新的研究领域,是以细胞内全部蛋白质的存在及其活动方式为研究对象,分析细胞内动态变化的蛋白质组成成份、表达水平与修饰状态,了解蛋白质之间的相互作用与联系。用蛋白质组学方法从蛋白质整体水平上研究鼻咽癌发生与转移,寻找与鼻咽癌发生及转移相关的新蛋白质、鼻咽癌特异性的标志物,对鼻咽癌的早期诊断和治疗起重要作用。本文从鼻咽癌治疗的分子靶点以及鼻咽癌特异性分子标志物等几个方面,详细介绍了近几年来鼻咽癌蛋白质组学的研究进展。
Proteomics is a new research field emerging in the post-genomic era. The purpose of this study is to investigate the existence and activity of all the intracellular proteins and to analyze the dynamic changes of intracellular protein components, expression levels and modified states, The interaction and contact between. Using proteomics to study the occurrence and metastasis of nasopharyngeal carcinoma from the overall level of protein, looking for new proteins and nasopharyngeal carcinoma-specific markers related to the occurrence and metastasis of nasopharyngeal carcinoma. From the early diagnosis and treatment of nasopharyngeal carcinoma Important role. In this paper, the molecular targets for the treatment of nasopharyngeal carcinoma and nasopharyngeal carcinoma-specific molecular markers, and several other aspects, introduced in recent years, the research progress of proteomics of NPC.