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强力霉素(DOX)治疗早期钩端螺旋体(钩体)病的研究,国内尚未见报告。随机采用DOX治疗钩体病19例,并以青霉素G(PNC-G)治疗15例作对照。两组病例都治愈,其主要征候持续时间无显著差异。但PNC-G组发生赫氏反应(JHR)11例(73.3％),其中1例(9.1％)演变成肺弥漫性出血,而DOX组无JHR发生。DOX和PNC-G对新分离出的8株钩体的体外抗菌活性良好。检测3例DOX组病人的血药浓度,服药期中都显著高于最低抑菌浓度。
Doxycycline (DOX) treatment of early Leptospira (leptospirosis) disease research, the domestic has not been reported. 19 cases of leptospirosis were randomly treated with DOX, and 15 cases were treated with penicillin G (PNC-G). Two groups of patients were cured, the duration of the main symptoms no significant difference. However, 11 cases (73.3%) of Hepatic reaction (JHR) occurred in PNC-G group, of which 1 case (9.1%) evolved into pulmonary diffuse hemorrhage, while no JHR occurred in DOX group. In vitro antibacterial activity of DOX and PNC-G against newly isolated leptospira was good. The plasma concentration of 3 DOX patients was significantly higher than the lowest inhibitory concentration in the medication period.