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目的 了解Graves眼病患者眼部组织的组织相容性抗原DR(HLA-DR)和热休克蛋白(HSP-70)的表达极其与病程和治疗的关系。方法 收集Graves眼病患者的眼外肌19例,通过免疫组化的方法观察HLA-DR和HSP-70在不同病程,治疗与未治疗患者眼外肌的表达差异。结果 HLA-DR在眼外肌的纤维母细胞、血管内皮细胞和浸润的淋巴细胞表达,以未治病人的眶组织为明显;HSP-70在肌细胞和纤维母细胞表达,病程短的病人其表达增强。结论 眼外肌细胞和纤维母细胞可能都是Graves眼病自身免疫反应的重要靶细胞;HLA-DR和HSP-70在自身免疫反应中起重要作用;病程和治疗影响HLA-DR和HSP-70的表达。
Objective To understand the histocompatibility of HLA-DR and HSP-70 in ocular tissue of patients with Graves ophthalmopathy and its relationship with the course of disease and treatment. Methods Nineteen cases of extraocular muscles from patients with Graves ophthalmopathy were collected. The expression of HLA-DR and HSP-70 in extraocular muscles of patients with different course of disease and with or without treatment were observed by immunohistochemistry. Results The expression of HLA-DR in extraocular muscles was significantly higher than those in non-treated orbital tissues. The expression of HSP-70 in myofibroblasts and fibroblasts with short course of disease Its expression is enhanced. Conclusion Both extraocular muscle cells and fibroblasts may be important target cells for autoimmunity reaction of Graves ophthalmology. HLA-DR and HSP-70 play an important role in the autoimmune response. The duration and treatment of HLA-DR and HSP-70 expression.