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采用９０只Ｗｉｓｔａｒ大鼠，以Ｄ半乳糖胺（Ｄｇａｌ）作为肝毒剂，建成急性肝损伤动物模型，筛选了最佳用药剂量，并研究了损伤后肝脏功能及组织形态的变化规律。结果表明，本实验条件下，Ｄｇａｌ４５０ｍｇ／ｋｇ体重为最适剂量，所致肝损伤组织形态变化显著且死亡率低（＜２４％），呈现的功能与形态变化程度一致，病变恒定。认为本模型可用于保肝新药的筛选与评价。
90 Wistar rats were used to treat D-gal as hepatotoxic agents to establish an animal model of acute liver injury. The optimal dose of D-gal was screened and the changes of hepatic function and histomorphology after injury were studied. The results showed that under the conditions of this experiment, D-gal450mg / kg body weight as the optimum dose, resulting in significant changes in liver injury tissue morphology and low mortality (<2 4%), showing the same degree of function and morphological changes, constant lesions . The model can be used for the screening and evaluation of new drugs for liver protection.