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目的：探讨药物对冠脉侧支功能的影响。方法：在１２只麻醉开胸狗上用冠脉左前降支制备侧支返流模型，缺血５ｍｉｎ后冠脉内注射尼可地尔（３００μｇ／ｋｇ）或生理盐水，在各不同时相上观测各侧支功能指标．缺血１２０ｍｉｎ后用氯化三苯四氮唑染色，称重法测定心梗范围．结果：与用药前相比，尼可地尔组在用药１５ｍｉｎ后各观测时相上冠脉侧支流量显著增加（１．５±０．４对０．９±０，６ｍｌ／ｍｉｎ，Ｐ＜０．０１），外周冠脉阻力和侧支系统阻力均显著下降（１．６±０．３对４．０±０．３ｋＰａ／ｍｌ·ｍｉｎ￣（－１），Ｐ＜０．０１；７．２±２．１对１２．０±２．１ｋｐａ／ｍｌ·ｍｉｎ￣（－１））．对照组上述各指标无明显变化．尼可地尔组心梗范围较对照组显著下降（２２．４±１．２％对２８．９±１．３％，Ｐ＜０．０１），结论：尼可地尔冠脉内注射可增加冠脉侧支流量，降低侧支系统阻力，并对缺血心肌有保护作用．
Objective: To investigate the effect of drugs on coronary collateral function. Methods: The models of collateral flow were established on the left anterior descending artery in 12 anesthetized open-chest dogs. Nicorandil (300 μg / kg) or saline was given intracoronary injection 5 min after ischemia. Observation of the collateral function index. 120min after ischemia with triphenyltetrazolium chloride staining, determination of myocardial infarction range. Results: In the Nicorandil group, the collaterals of coronary arteries were significantly increased at 15 min after administration (1.5 ± 0.4 versus 0.9 ± 0.6 ml / min, P < 0.01). The resistance of peripheral coronary artery and collateral system were significantly decreased (1.6 ± 0.3 versus 4.0 ± 0.3 kPa / ml · min ~ (-1), P <0.01; 7 .2 ± 2.1 vs. 12.0 ± 2.1 kpa / ml · min ~ (-1)). The control group of the above indicators no significant change. Nicorandil group myocardial infarction range significantly lower than the control group (22.4 ± 1.2% vs 28.9 ± 1.3%, P <0.01), Conclusion: Nicorandil intracoronary injection may be Increased coronary collateral flow, reduce collateral system resistance, and myocardial ischemia have a protective effect.